Ketamine therapy is a treatment approach that uses low doses of ketamine, a dissociative anesthetic medication, to manage various mental health conditions, such as treatment-resistant depression, anxiety disorders, and post-traumatic stress disorder (PTSD).

Usually ketamine treatment includes one or a few in-clinic ketamine dosing sessions under clinician supervision integrated with preparatory and integration counseling.

Ketamine works by blocking the activity of the N-methyl-D-aspartate (NMDA) receptor, a receptor in the brain that is involved in the regulation of mood, cognition, and pain perception. Ketamine therapy is thought to have rapid-acting antidepressant effects, with many patients reporting improvements in their symptoms within hours to days after treatment.